The Deception of Methylene Blue: A Synthetic Toxin Disguised as a Holistic Remedy by a guest author
Methylene blue, along with several other synthetic compounds, has become the centerpiece of an aggressive marketing campaign designed to mislead the public. Proponents of this entirely artificial substance falsely present it as a natural and holistic solution for a wide range of health concerns—claiming benefits from cognitive enhancement and mitochondrial support to heavy metal detoxification. This is nothing short of pure deception, an elaborate ploy intended to lure unsuspecting individuals into consuming a substance that, in reality, serves a far more insidious function: the inhibition of CYP450 enzymes—our body’s essential defense mechanism against toxins.
Make no mistake: methylene blue is a toxin. While the extent of its harmful effects goes beyond just CYP450 inhibition, I will focus solely on this aspect in this post. However, if there is interest, I am prepared to expand on its broader toxicological profile.
What is truly alarming is how easily people are misled. Is it really enough to repeat a claim for the masses to believe it? We are told that methylene blue is “natural” and “holistic,” despite being entirely synthetic. We are led to believe it miraculously participates in almost every essential biological process, allegedly curing cancer, reversing neurodegeneration, detoxifying heavy metals, healing wounds, fractures, and infections. But these are all blatant fabrications. The actual role of methylene blue is to sabotage our body’s natural detoxification systems, allowing harmful foreign substances to penetrate deep into our tissues—potentially with long-term, devastating consequences.
The Larger Agenda: A Coordinated Chemical Assault
To understand why such a campaign is being pushed so aggressively, one must acknowledge the broader picture: we are being chemically attacked. This is not speculation—it is an undeniable pattern that has been unfolding for decades.
Consider the 1970s, when one of the most sophisticated toxins in human history, glyphosate, was introduced into our food and water supply. That alone was not enough. The agenda has since escalated, shifting towards even more covert biological sabotage. The ultimate goal? Control over population growth—not through education or economic reform, but through chemical castration and engineered disease.
Instead of addressing overpopulation through sustainable development—eradicating poverty, ensuring clean water access, and fostering responsible family planning—those in power have chosen a different path. They have weaponized chemistry, deploying biochemical agents like methylene blue under the guise of “health innovations” to gradually compromise human vitality.
Enormous financial resources are funneled into paid influencers, shills, and corrupted health authorities, ensuring the narrative remains unquestioned. These people are not looking out for your well-being—they are playing a role in an orchestrated manipulation.
The Bottom Line: Stay Vigilant
We still have something invaluable here—the truth. Do not let them take it from you. Do not be fooled by glossy narratives, manufactured consensus, or so-called “experts” who echo the same carefully curated script.
If you care about your health, your future, and the generations to come, resist this deception and spread awareness. We must not allow these toxic agendas to succeed.
Cytochrome P450 enzymes (CYP450) are like the body’s chemical processing plants. They help break down and modify substances, including medications, toxins, and even food components, so that the body can use them properly or get rid of them.
What Do CYP450 Enzymes Do?
1. Drug Metabolism – They help the body process medicines, making them more or less active, or easier to eliminate.
2. Detoxification – They break down harmful chemicals, preventing them from building up in the body.
3. Hormone Production – They help create important hormones like estrogen and testosterone.
Why Are They Important?
They control how long drugs stay in your system. Some people have fast CYP450 enzymes, so drugs break down quickly, while others have slow ones, making drugs last longer.
They influence drug interactions. If one drug blocks a CYP450 enzyme, another drug might stay in the body too long, increasing side effects.
Genetic differences mean that some people process drugs differently, which is why the same medicine may work well for one person but not another.
CYP450 & Methylene Blue
Methylene blue can slow down CYP450 enzymes, affecting how other drugs are broken down. This can lead to higher levels of certain medications in the body, increasing the risk of side effects.
Here are references that discuss this interaction:
ResearchGate Study: This in vitro assessment identifies methylene blue hydrate as a multiple CYP450 inhibitor and a mechanism-based inhibitor.
FDA Label for Provayblue (Methylene Blue) Injection: The label notes that methylene blue inhibits a range of CYP isozymes in vitro, including 1A2, 2B6, 2C8, 2C9, 2C19, 2D6, and 3A4/5.
https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/204630s005lbl.pdf
Medsafe Data Sheet for Proveblue: This document states that methylene blue is an in vitro inhibitor of CYP450 enzymes, specifically 1A2, 2B6, 2C8, 2C9, 2C19, 2D6, and 3A4/5.
https://www.medsafe.govt.nz/profs/datasheet/p/proveblueinj.pdf
PubMed Study on Indoleamine 2,3-Dioxygenase (IDO) Activity: This research indicates that the addition of methylene blue to NADPH-cytochrome P450 reductase (CPR)-supported reactions resulted in inhibition of d-tryptophan turnover, suggesting an inhibitory effect on CYP450-related processes.
https://pubmed.ncbi.nlm.nih.gov/20178337
PubMed Study on Nitric Oxide Synthesis: This study reports that methylene blue inhibits nitric oxide synthase activity, which is related to CYP450 enzymes, indicating its role as an inhibitor in these pathways.
https://pubmed.ncbi.nlm.nih.gov/7679577
Besides CYP450 inhibition. Here is a list of what this toxin does:
Methylene Blue: Mechanisms, Interactions, and Risks
1. CYP450 Enzyme Inhibition
- CYP2D6 Inhibition: Strong inhibitor, affects metabolism of antidepressants, beta-blockers, opioids, and antipsychotics.
- CYP2C9 and CYP3A4 Inhibition: Weak inhibition, may alter metabolism of some drugs.
2. Mechanism of Inhibition
- Leads to increased plasma concentrations, enhancing toxicity or side effects.
3. Drug Interactions
- Serotonergic Drugs (SSRIs, SNRIs, TCAs, tramadol, meperidine, dextromethorphan, buspirone, triptans): Risk of serotonin syndrome.
- Beta-Blockers (metoprolol, propranolol, carvedilol): Increased effects, risk of bradycardia or hypotension.
- Opioids (codeine, tramadol): Altered activation, increased side effects.
- Antipsychotics (risperidone, haloperidol, aripiprazole): Increased drug levels, potential toxicity.
- Antiarrhythmics (flecainide, propafenone): Increased plasma concentration, possible cardiac effects.
- Tamoxifen: Reduced activation, increased side effects.
- Anesthetics: Possible cardiovascular instability.
- Stimulants: Increased risk of hypertensive crisis or serotonin syndrome.
- Lithium: Potential neurotoxicity.
- MAO Inhibitors (phenelzine, tranylcypromine, isocarboxazid, selegiline, linezolid): Risk of hypertensive crisis and serotonin syndrome.
4. Serious Side Effects
- Serotonin Syndrome: Agitation, confusion, tachycardia, hypertension, muscle rigidity, hyperthermia, seizures, coma.
- Hemolytic Anemia: Particularly in individuals with G6PD deficiency.
- Methemoglobinemia: Oxygen delivery impairment, paradoxically worsened by high doses.
- Neurological Effects: Confusion, delirium, seizures, headache, dizziness.
- Cardiovascular Effects: Hypertension, arrhythmias, chest pain.
- Respiratory Effects: Shortness of breath, respiratory distress.
- Gastrointestinal Effects: Nausea, vomiting, abdominal pain.
- Skin Discoloration: Bluish tint with prolonged use.
- Allergic Reactions: Rash, itching, anaphylaxis.
- Kidney or Liver Stress: Possible dysfunction with prolonged use.
5. Toxicity Risks
- Mitochondrial Inhibition: Can lead to cellular energy depletion.
- Oxidative Stress: High doses may generate reactive oxygen species (ROS), causing tissue damage.
- Serotonin Reuptake Inhibition: Increases serotonin, compounding risk of serotonin syndrome.
- Multi-Organ Failure: Extreme overdose can lead to widespread toxicity.
6. Special Populations at Risk
- G6PD Deficiency: Risk of hemolysis.
- Elderly Patients: Increased risk of neurological side effects.
- Pregnant Women: Risk of fetal harm (intestinal atresia, methemoglobinemia).
7. Rare Complications
- Acute Respiratory Distress Syndrome (ARDS): Severe lung injury.
- Chronic Methemoglobinemia: Long-term use may worsen oxygen transport.
- Cumulative Toxicity: Drug accumulation leading to systemic effects.
- Intraoperative Use: Rare complications like anaphylaxis or tissue necrosis.
- Environmental Impact: Potential harm to aquatic ecosystems.
If you’d like to know more, feel free to reach out.
I recommend absolutely avoiding it—and other artificial, synthetic toxins like ivermectin and fenbendazole, as well as all pharmaceutical drugs. Stick to natural methods, and follow what we do here.
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We also do not need Methylene Blue as a methylator. There are many safe methylators: MSM Sulfur, iodine, and copper.
See also: