Manganese Interactions and Doses

Manganese Interactions and Doses

We are taking 1-2 pills of 8 mg of manganese daily.
This brand:

After 1 week on manganese, I’m noticing super long super vivid super detailed dreams, less flipping over in bed and sleeping longer in one position without having to move, better joints in the gym, warmer hands, and I think slightly better thinking ability.

Our full Protocol:

There is no RDA for Manganese. Only an AI (Adequate Intake) 2 mg. Most people get 2 mg.
Deficiency is very rare. Toxicity is very rare.

And, like always, blood testing does not work, and testing is rarely done!

“No evidence shows manganese toxicity from high dietary manganese intakes [38].”

“The ULs do not apply to individuals who are taking supplemental manganese under medical supervision.”

The Upper Limit for Adults is 11 mg. (including pregnant and breastfeeding adults)

From Jonathan Harris on manganese enzymes and benefits:

I address Manganese Toxicity Concerns:

10 Evidence-Based Benefits of Manganese (2023)

1 improved bone health
2 antioxidant (SOD superoxide dismutase), detoxing, helping arthritis, heart disease, free radicals, disease
3 lowers inflammation, osteoarthritis, joint pains.
4 regulates blood sugar
5 less seizures
6 metabolize nutrients; energy production
7 less PMS symptoms (pre menstrual)
8 improved brain function (SOD again)
9 thyroid health, making thyroxine
10 aids wound healing, collagen production



“Manganese and Man”

“a clear-cut
case of Mn deficiency in humans had never been
proven. Then, during an experiment in which
Doisy (1973) was studying vitamin K
deficiency, Mn was inadvertently left out of the
diet mixture being fed to the patient. This patient
underwent weight loss, transient dermatitis,
nausea, and slow growth of hair and beard with
changes in hair color. Biochemically, there was
striking hypocholesterolemia. With recognition
of the error, the stage was set for more intensive
research into Mn and its biochemical roles. “


The finding of a
lowered Mn blood level with prolonged zinc
supplementation has occurred in psychiatric,
arthritic, senile and cardiac patients. Thus all
diagnostic categories can be harmed by large
prolonged doses of zinc without Mn. With this
new concept we have treated problem patients
with large oral doses of Mn. In one severely
allergic male, age 45, whom we had treated
for 14 years, we suggested 50 mg of Mn as the
gluconate morning and night. He felt
somewhat better with this dose, so he
cautiously increased the dose to 100 mg, three
times per day. Before starting this dose his
blood Mn was six ppb (11/7/79). After three
months of the big dose, his blood Mn was 11
ppb (4/22/80). On 5/20/80 the level was 8.5
ppb. Normal is 10 to 20 ppb. Physical
examination, blood pressure, pulse and
chemscreen showed no abnormalities. During the
period of 300 mg Mn orally per day he gained
11 needed pounds in body weight and was
able to tolerate foods that normally caused
depressive reactions.


In summary then, the high copper level of
schizophrenics, arthritics and patients with
psoriasis can be reduced by dietary intake of
zinc and Mn. Manganese is more effective than
zinc in increasing urinary copper excretion; a
combination of zinc and Mn is more effective
than either alone.

“Upon an injury, athletes should take up to 200 mg [manganese] per day in divided dosages for a two week period.”

Manganese – lowers ammonia, is pro-collagen, pro-steroidogenesis and boosts immunity

September 20, 2017 by Hans Amato

Manganese – lowers ammonia, is pro-collagen, pro-steroidogenesis and boosts immunity

“If you have inflamed, sore joints, try this trick out from Vince Gironda:

  • 200mg manganese every 3 hours for three days. This will knock that inflammation right out. (very potent)


  • 30mg x3 day for 2 weeks. (more chill)”

Ammonia is a byproduct of protein breakdown. A buildup of ammonia can lead to impaired memory, shortened attention span, sleep-wake cycle disruption, brain edema, intracranial hypertension, seizures, ataxia, and coma and is also neurotoxic.”

Arginase, the fifth and final enzyme of the urea cycle, is ubiquitous in living systems, and depends upon Mn as a cofactor. This enzyme converts the amino acid arginine to ornithine as well as ammonia to urea. The urea is then released into the bloodstream where it travels to the kidneys and is ultimately excreted in urine.

Mn also helps to prevent and decrease kidney stones, as it is a cofactor in the metabolism/breakdown of oxalates in the liver.”

See the whole article above for more good info. Next, continuing on to more information about potential doses.


Manganese Gluconate at Amazon:

On the package, it says 225 mg per serving.

As a dietary supplement take 225 mg (about 1/10 tsp) once daily with water, or as directed by a physician. Use an accurate milligram scale to measure.

[I SUSPECT IT’S 225 MG OF MANGANESE GLUCONATE, THE POWDER, because it also says 1111 servings, and 250 grams per container.]

Is it toxic? What is the evidence, and at what level?
No toxic dose listed. Upper Limit defined at 11 mg. However…

“The ULs do not apply to individuals who are taking supplemental manganese under medical supervision.”

Mechanisms of manganese-induced neurotoxicity and the pursuit of neurotherapeutic strategies

No toxic dose listed. Toxicity is observed only in occupational settings, and by blood correlational studies (which cannot prove causation).

Manganese-Induced Neurotoxicity: New Insights Into the Triad of Protein Misfolding, Mitochondrial Impairment, and Neuroinflammation (2019)

No toxic dose listed. Toxicity is not observed from supplementation, but only through air exposure, work exposure and TPN.

“Manganese-induced neurotoxicity: a review of its behavioral consequences and neuroprotective strategies” (2016)

No toxic dose listed. They repeat that fumes, water, and TPN can cause manganese toxicity.

“…neuroprotective strategies have been reported, and these include endogenous antioxidants (for instance, vitamin E), plant extracts (complex mixtures containing polyphenols and non-characterized components), iron chelating agents, precursors of glutathione (GSH), and synthetic compounds (metal chelators?) that can experimentally afford protection against Mn-induced neurotoxicity.”

Copper and zinc make powerful antioxidants such as SOD. MN is also needed for another form of SOD!

Manganese and the brain (2013)

No toxic dose listed.

“Although essential, Mn is toxic at high concentrations.”

“Mn neurotoxicity has been attributed to impaired dopaminergic (DAergic), glutamatergic and GABAergic transmission, mitochondrial dysfunction, oxidative stress, and neuroinflammation.”

“Current treatment strategies for Mn toxicity combine chelation therapy to reduce the body Mn load and iron (Fe) supplementation to reduce Mn binding to proteins that interact with both Mn and Fe.”

Manganese neurotoxicity (2004)

No toxic dose listed.

Manganese action in brain function (2003)

No toxic dose listed!

Abnormal concentrations of manganese in the brain, especially in the basal ganglia, are associated with [associations do not prove causation] neurological disorders similar to Parkinson’s disease.

Looking up the LD50 for manganese: 325 pages!

Oral doses for rats and mice are around 500 mg /kilo to 2000 mg/kilo for the lowest observed effects, for oral exposures.

Vegans can get more than 10.9 mg of manganese a day from food, p. 224.

” the influence of manganese oxidation state on manganese toxicity is not currently well understood.” 556 pages!

I asked Chat at bing the following question about this report:

Can you determine the toxic amount of manganese from supplements from this page on the toxicological profile for manganese?

“According to the web page on the toxicological profile for manganese, there is no clear evidence of toxicity from manganese supplements in humans.”

I then asked: What does this document say about human oral doses of manganese, excluding exposures to the air?

“No oral minimal risk levels (MRLs) were derived for acute-, intermediate-, or chronic-duration oral exposure to manganese, but an interim guidance value of 0.16 mg manganese/kg/day is recommended for ATSDR public health assessments.”

This is 16 mg for a 100 kilo man.

An indirect way to review the benefits of MN is to look at the benefits of MnSOD:

Insights into Manganese Superoxide Dismutase and Human Diseases

This repeats many of the benefits of manganese listed above.

The Functional Role of MnSOD as a Biomarker of Human Diseases and Therapeutic Potential of a New Isoform of a Human Recombinant MnSOD