We are Taking Niacin Again - RevealingFraud.com

As of August 2, 2024, We took 500 mg of niacinamide last night. This ended our 2 month experiment of not taking any Niacin.

We reviewed the symptoms of Niacin deficiency, and we noticed a few of them, as follows, from our list here:
https://revealingfraud.com/2024/06/health/the-problems-with-niacin/

We noted:
Decreased tolerance to cold
–One night, with the thermostat at 70 degrees, as normal, I just felt very cold. It might have been from overtraining, or might have been from low niacin.

Dementia (cognitive impairment) Yesterday evening, as we went out to eat, I forgot my wallet.

Diarrhea + Twice in the last two days.

Dermatitis (skin inflammation) Jennifer, not me.

Insomnia — We both had a bit of insomnia.

Loss of appetite — I find I’m forcing myself to eat.

We took the Niacin in the evening with our zinc. We slept so deeply. So it seems we got a bit deficient, with little doubt. We did not develop any neck rash.

We have experimented with taking Niacin on and off. The last time we stopped Niacin, we stopped for about 3 weeks, and we took it again, due to a slight rash around the neck.

Just before going off of Niacin, we were experimenting with taking all of our B Vitamins most every day, including 500 mg Niacin in the form of Niacinamide. But this led to a rash on our heads, and a bit of dandruff, which I never have. And this was a symptom of excess Niacin. I think we were also feeling more fatigued. And I was concerned about one of Niacin’s effect, it stops people, AND ANIMALS, from running, and I felt like it was harming our ability to run.

When stopping Niacin, it felt easier to run again. High niacin has some effects that negatively impact running. It reduces the ability to burn blood sugars and can worsen diabetes. It weakens and lengthens tendons (great for arthritis, bad for needing the rebounding effect of tendons for running). Excess niacin can also cause shortness of breath, which is horrible for running.

Some people have noticed problems of excess niacin merely in the food supply, which provides only about 30-40 mg of niacin. We may need more niacin on high copper. Why? Symptoms of Niacin excess appear to be symptoms of copper deficiency, and it is noted that Niacin can deplete copper. Therefore, it’s possible that, conversely, high copper can deplete niacin, although there are no studies to indicate this, in part, because there are no studies on high copper. We are paving the way. Our new theory is as follows: Niacin and copper are both used to make ATP. As ATP is increased, the presence of copper can use up, and thereby deplete Niacin more quickly than it would be used up otherwise.

It is odd that high niacin can cause fatigue, and I don’t think that’s just from copper depletion. So, I asked claude.ai

Jason: Why does Niacin at 500 mg cause drowsiness if it increases ATP?

Claude.AI:

Your question highlights an interesting paradox in niacin’s effects. Let’s break this down:

Niacin and ATP production:
You’re correct that niacin is crucial for ATP production. As a precursor to NAD+ and NADP+, it plays a vital role in cellular energy metabolism.
Niacin and drowsiness:
The drowsiness experienced with high-dose niacin (like 500 mg) is not directly related to its role in ATP production. Instead, it’s likely due to several other mechanisms: a) Prostaglandin D2 (PGD2) release:

High-dose niacin stimulates the production of PGD2 in the skin.
PGD2 can cross the blood-brain barrier and promote sleep by activating the DP1 receptor in the brain. b) Serotonin modulation:
Niacin can influence serotonin metabolism.
Changes in serotonin levels can affect sleep-wake cycles. c) Vasodilation:
Niacin causes vasodilation, which can lead to a drop in blood pressure.
This can contribute to feelings of relaxation and drowsiness. d) Glucose metabolism:
High doses of niacin can affect glucose metabolism, potentially leading to transient changes in blood sugar levels.
These fluctuations might contribute to feelings of fatigue or drowsiness.

Dosage matters:
The effects of niacin are dose-dependent. At 500 mg, you’re well above the recommended daily intake (14-16 mg for adults), entering the realm of pharmacological effects.
Individual variation:
Not everyone experiences drowsiness with high-dose niacin. Individual responses can vary based on factors like metabolism, body composition, and overall health status.
Timing considerations:
The drowsiness effect is often more pronounced when niacin is taken at night or on an empty stomach.

It’s important to note that while niacin does increase ATP production at a cellular level, this doesn’t necessarily translate to an immediate feeling of energy or alertness. The body’s response to high-dose niacin involves multiple systems and pathways, leading to complex and sometimes counterintuitive effects.

…edit out…

===end claude.ai===

Our next experimental dose will be to try only 100 mg of Niacin per week, as the 500 mg dose appears to be too high. We might modify that at any time.

If we feel we need more niacin, we will do another update.

Update! As of August 28th. It seems 100 mg of Niacin a week was too little. I started getting achy feet “from running”. Two night ago, I also had insomnia, and this week, a bit of diarrhea, all low Niacin symptoms. Two nights ago, I took 100 mg Niacin. Yesterday, I took 500 mg Niacin. Today, my feet suddenly feel fantastic, and I slept fantastic. It seems I may need about 100 mg of Niacin per day, not per week, and that will be my next level of Niacin to test.

At the same time as trying to figure out how little Niacin I can “get away with”, I’ve also been increasing copper this week to around 50 mg per day. Copper may be depleting the Niacin, and I may need more niacin with the increased copper.